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Use in patients with known hypersensitivity to pioglitazone, glimepiride or any other component of the formulation.
Initiation in patients with established NYHA Class III or IV heart failure.
Use in patients with known history of an allergic reaction to sulfonamide derivatives.
Reported hypersensitivity reactions with glimepiride include cutaneous eruptions with or without pruritus as well as more serious reactions (e.g., anaphylaxis, angioedema, Stevens Johnson Syndrome, dyspnea).
